Welcome to the Molecular Motors Laboratory
Dyneins are microtubule-based molecular motors that power both ciliary/flagellar motility and a variety of essential intracellular motile events. In order for these massive enzymes to function correctly, they must be attached to the appropriate cargo and motor activity must be precisely regulated. Over the last few years we have identified a series of highly intriguing dynein components that appear to be involved in these regulatory activities. Current focus in the laboratory is on understanding the mechanisms which control motor function using a wide variety of techniques ranging from physiological measurements and genetic analyses to structural biology.